Professor David Paterson

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 Email: d.paterson1@uq.edu.au

David L. Paterson is a Professor of Medicine at The University of Queensland Centre for Clinical Research (UQCCR), and Chief Executive Officer of Wesley Medical Research. He is also a Consultant Infectious Diseases Physician, and Consultant Microbiologist.

Professor Paterson's clinical work, research and teaching has been honoured and recognised internationally, most recently in the 2015 Thomson Reuters Highly Cited List.  He received both his medical degree and PhD from The University of Queensland. In 2007, Professor Paterson returned to Brisbane after spending ten years at The University of Pittsburgh School of Medicine, one of the leading academic medical institutions in The United States. His work at The University of Pittsburgh Medical Center included appointments as Chief of Transplant Infectious Diseases and Director of the Antibiotic Management Program. In 2000 he was one of two recipients of the prestigious American Society for Microbiology (ASM) Merck Irving Sigal Memorial Award for "Significant Research in Microbiology and Infectious Diseases". He received the 2008 Frank Fenner Award for Advanced Research in Infectious Diseases by the Australasian Society for Infectious Diseases (ASID) and in 2009 he was the winner of a Queensland Health Senior Clinical Research Fellowship.

Professor Paterson is the author of more than 235 peer-reviewed publications, of which nearly half have been published in the last three years. He has authored more than 30 book chapters and is a member of the editorial board of two leading Infectious Diseases journals. He is regularly invited to speak at leading national and international conferences and has lectured in 27 countries.

His research interest includes study of the molecular and clinical epidemiology of infections with antibiotic resistant organisms. The focus of this work is the translation of knowledge into optimal prevention and treatment of these infections. Professor Paterson has received research funding from the Centers for Disease Control and Prevention (CDC) and the National Health and Medical Research Council (NHMRC).

Professor Paterson has mentored a number of prominent emerging leaders in the field of Infectious Diseases. These include Anton Y. Peleg MBBS FRACP, 2009 winner of the ASM Merck Irving Sigal Memorial Award, and two Assistant Professors based at The University of Pittsburgh Medical Center, Yohei Doi MD PhD and Fernanda Silveira MD.

 

Research Projects

Project title

Granting body

Years of funding

"Optimizing dosing of colistin for infections resistant to all other antibiotics"

National Institute for Allergy and Infectious Diseases

2007-2012

"Prevention and treatment of infections with antibiotic resistant bacteria"

Queensland Government

2010-2014

"Clinical implication of newer beta-lactamases"

NHMRC Practitioner Fellowship

2010-2014

"Centre for Research Excellence in Reducing Healthcare Associated Infection"

NHMRC Centre for Research Excellence Grant

2011-2016

"Membrane-targeted antibiotic for complicated skin and skin stucture (cSSSI) infections caused by MRSA, VISA, and VRE (Methicillin and Vancomycin-resistant S. aureus and enterococci)"

Wellcome Trust Grant

2011-2013

Clostridium difficile: assessing the risks to Australia of an emerging healthcare-related pathogen"

NHMRC Project Grant

2011-2013

Recent Publications

Paterson DL, Harris PN; Colistin resistance: a major breach in our last line of defence. Lancet Infect Dis. 2015 Nov 18. pii: S1473-3099(15)00463-6.

Zowawi HM, Forde BM, Alfaresi M, Alzarouni A, Farahat Y, Chong TM, Yin WF, Chan KG, Li J, Schembri MA, Beatson SA, Paterson DL; Stepwise evolution of pandrug-resistance in Klebsiella pneumoniae. Sci Rep. 2015 Oct 19;5:15082.

Dulhunty JM, Roberts JA, Davis JS, Webb SA, Bellomo R, Gomersall C, Shirwadkar C, Eastwood GM, Myburgh J, Paterson DL, Starr T, Paul SK, Lipman J; BLING II Investigators for the ANZICS Clinical Trials Group*; A Multicenter Randomized Trial of Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis. Am J Respir Crit Care Med. 2015 Dec 1;192(11):1298-305.

Harris PN, Peleg AY, Iredell J, Ingram PR, Miyakis S, Stewardson AJ, Rogers BA, McBryde ES, Roberts JA, Lipman J, Athan E, Paul SK, Baker P, Harris-Brown T, Paterson DL; Meropenem versus piperacillin-tazobactam for definitive treatment of bloodstream infections due to ceftriaxone non-susceptible Escherichia coli and Klebsiella spp (the MERINO trial): study protocol for a randomised controlled trial. Trials. 2015 Jan 27;16:24.

Rogers BA, Ingram PR, Runnegar N, Pitman MC, Freeman JT, Athan E, Havers SM, Sidjabat HE, Jones M, Gunning E, De Almeida M, Styles K, Paterson DL; Community-onset Escherichia coli infection resistant to expanded-spectrum cephalosporins in low-prevalence countries. Australasian Society for Infectious Diseases Clinical Research Network. Antimicrob Agents Chemother. 2014;58(4):2126-34. 

List of Publications

Contact details and email

The University of Queensland Centre for Clinical Research (UQCCR)

PROFESSOR OF MEDICINE

David L. Paterson

The University of Queensland, Building 71/918 RBWH Herston QLD 4029

Telephone: (07) 3346 6074

Facsimile: (07) 3346 5598

Email: d.paterson1@uq.edu.au

Group Members

Professor David Paterson, MBBS PhD FRACP FRCPA, Group Leader

Dr Charlotte Huber, PhD, Postdoctoral Research Fellow

Dr Minyon Avent, B Pharm B Sc (Hons) Pharm D BCPS, Clinical Research Pharmacist

Dr. Patrick Harris, MBBS FRACP FRCPA, PhD Student

Mr Alexander Wailan BSc (Hons), PhD student

Dr Vikram Vaska, MBBS FRACP FRCPA, PhD Student

Dr. Kate McCarthy, MBBS FRACP FRCPA, PhD Student

Mr Hosam Zowawi, BAppMicro, MClinSc (ClinMiro) (Hons), PhD Student

Ms Tiffany Harris-Brown, RN MPH, Clinical Research Manager

Ms. Penny Lorenc, RN, Clinical Research Nurse

Ms. Luminita Vlad, Executive Assistant

Dr. Elda Righi, Researcher

Former Paterson Group Members

Dr Tatsuo Nagashima, MD PhD Post-doc Researcher (Mater Mother's Hospital)

Dr Pilar Retamar MD, PhD ( Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Sevilla, Spain)

Dr Hisashi Baba (2008-2009), Visiting Academic Researcher (Nagoya University Hospital)

Dr Fatimah Abdullah (2008-2009), Visiting Academic Researcher (Hospital Sultanah Nur Zahirah)

Dr Ahmad Rahman (2008-2009), Visiting Academic Researcher (Hospital Sultanah Nur Zahirah)

Dr Baek-Nam Kim (2008), Visiting Academic Researcher (Inje University Sanggye-Paik Hospital)

Dr Marjolein Deege (2009-2010), Microbiology Researcher (University Medical Centre Utrecht)

Dr Claire Heney (2008), Microbiology Researcher (Princess Alexandra Hospital)

Dr Mariam Noureddine López, MD (2010), Visiting Clinical Researcher (Department of Internal Medicine, Costa del Sol Hospital)

Dr Kenichiro Morisawa, MD PhD, Visiting Academic Researcher

Dr Zohreh Aminzadeh, MD MPH, Visiting Academic Researcher

Ms Syamhanin Adnan, B Pharm M Clin Pharm, PhD student

Dr Witchuda Kamolvit (2015 completed), PhD Student

Dr Linda Robertus, MD, PhD student

Dr Ben Rogers (2014 completed), MBBS FRACP, PhD Student

Dr Yoshiro Hayashi, MD PhD, Postdoctoral Honorary Research Fellow

Ms Sally Havers, RN, Senior Clinical Research Manager

Dr Anna Silvey, PhD, Researcher

Ms Laurie Beechey, Executive Assistant

Miss Leisha Richardson, BAppSci(Hons), Senior Research Assistant

Terence (Kwee Yong) Seah, BSc, Hons Student

Lisha Keane, BBusMan BCommun, Project Officer

Dr Hanna Sidjabat, PhD, Research Laboratory Leader

Dr. Maria Diletta Pezzani, Visiting Academic Researcher (Ospedale Luigi Sacco, Milan, Italy)

Dr. Anna Peri, Visiting Academic Researcher (Ospedale Luigi Sacco, Milan, Italy)

 

Funding acknowledgement

Professor Paterson was Principal Investigator on a major grant from the National Institutes of Health (budget $US3.4 million) for the project "Optimizing dosing of colistin for infections resistant to all other antibiotics". Additionally, two significant grants have been received from the Centers for Disease Control and Prevention: "Organ transplant infection prevention"; and "Validation of National Committee for Clinical Laboratory Standards Breakpoints for Organisms of Public Health Importance".

Professor Paterson is currently a Chief Investigator on two project grants from the NHMRC: "Predicting the risk of invasive candidiasis in critically ill patients"; and: "Antibiotic dosing in the 'at risk' critically ill patient".

 

Collaborations

International

University of Pittsburgh School of Medicine

Dr Fernanda Silveira and Dr John Kellum

Pharmacokinetics of colistin

NIH grant "Optimizing dosing of colistin for infections resistant to all other antibiotics".

Joint publications: 11

Dr Yohei Doi

Newer beta-lactamases

Grant : AstraZeneca "Gram negative bacteremia"

Joint publications : 17

Harvard University

Dr Anton Peleg

Acinetobacter infections

Joint publications : 10

University of Colorado

Dr Douglas Fish

Pharmacokinetics of colistin

NIH grant "Optimizing dosing of colistin for infections resistant to all other antibiotics".

University at Buffalo

Dr Alan Forrest

Pharmacokinetics of colistin

NIH grant "Optimizing dosing of colistin for infections resistant to all other antibiotics".

Centers for Disease Control and Prevention

Drs Tom Chiller, Ben Park and Scott Fridkin

Infections in transplant recipients

CDC grant "Organ transplant infection prevention"

University of Alabama

Dr Pete Pappas

Infections in transplant recipients

CDC grant "Organ transplant infection prevention"

The Cleveland Clinic Foundation

Drs Robyn Avery and Steve Gordon

Infections in transplant recipients

CDC grant "Organ transplant infection prevention"

Case Western Reserve University

Drs Robert Bonomo, Louis Rice and Curtis Donskey

Newer beta-lactamases

CDC grant: Validation of National Committee for Clinical Laboratory Standards Breakpoints for Organisms of Public Health Importance

Joint publications: 18

Mahidol University, Bangkok

Dr Visanu Thamlikitkul

Pharmacokinetics of colistin

NIH grant "Optimizing dosing of colistin for infections resistant to all other antibiotics".

Hospital Universitario Virgen Macarena, Seville, Spain

Drs Jesus Rodriguez-Bano and Pilar Retamar

Newer beta-lactamases

Joint publication: 2

Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Germany

Dr Harald Seifert

Acinetobacter infections

Joint publication: 1

Semmelweis University, Budapest, Hungary

Dr Dora Szabo

Newer beta-lactamases

Joint publications: 9

National

Prof. Roger Nation

Monash University

Pharmacokinetics of colistin

NIH grant "Optimizing dosing of colistin for infections resistant to all other antibiotics".

Joint publication: 1

Prof. Tania Sorrell

University of Sydney

Infections in the critically ill

NHMRC grant: Predicting the risk of invasive candidiasis in critically ill patients.

Prof. Jeffrey Lipman

The University of Queensland

Infections in the critically ill

NHMRC grant: "Antibiotic dosing in the "at risk" critically ill patient".

Joint publications: 2

Dr Mark Schembri

The University of Queensland

Acinetobacter infections

NHMRC Proposal. Understanding the Acinetobacter genome.

Dr Scott Beatson

The University of Queensland

Acinetobacter infections

NHMRC Proposal. Understanding the Acinetobacter genome.

Dr Matthew Cooper

The University of Queensland

Development of new antibiotics

NHMRC proposal. Semi-synthetic derivatives of vancomycin and colistin