Dr Peter Simpson

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Dr Peter Simpson
BSc (Hons), PhD, FRCPA
Senior Lecturer, UQ School of Medicine
Research Group Leader, UQCCR

Email Icon p.simpson@uq.edu.au
Phone +61 7 334 66051
RG ResearchGate


Peter holds a Science Honours degree and a PhD in Molecular Biology from the University of Liverpool in the UK. He moved to Australia in 2004 and helped Professor Lakhani establish the MBP group. He is a past NBCF Early Career Fellow, a Fellow of the Royal College of Pathologists of Australasia, and currently holds a joint teaching and research position at UQ (School of Medicine and UQCCR).

 
Research interests
Breast cancer is a very heterogeneous disease, making morphological classification and management of patients a significant challenge. For example, it remains difficult to predict which patients are at risk of their disease returning (recurrence), spreading (metastasis) or which patients will respond to a specific treatment. There has therefore been a concerted effort to supplement the morphological classification of breast disease with molecular parameters that can provide a clearer appreciation for this complexity and better predict tumour behaviour. This ideology has driven significant advancements in the field of molecular pathology research.

Invasive Lobular Carcinoma (ILC) are a common special subtype of breast cancer comprising up to 15% of all cases. They exhibit a very characteristic set of clinical, pathological and biological properties, including a progressive decline in survival, an infiltrative pattern of growth and down regulation of cell adhesion molecule, E-cadherin. Morphological variants exist that are associated with a worse outcome compared to the classic type. A large component of Peter's research focuses on aspects of this specific disease subtype, including understanding molecular determinants that predict tumour behaviour, and mechanisms of invasion and metastasis.

Funding acknowledgement
The National Health and Medical Research Council (NHMRC)
The National Breast Cancer Foundation (NBCF)
The University of Queensland

Students
Samir Lal
Renique Males
Liana Dedina