Breast cancer is a very heterogeneous disease, making morphological classification and management of patients a significant challenge. For example, it remains difficult to predict which patients are at risk of their disease returning (recurrence), spreading (metastasis) or which patients will respond to a specific treatment. There has therefore been a concerted effort to supplement the morphological classification of breast disease with molecular parameters that can provide a clearer appreciation for this complexity and better predict tumour behaviour. This ideology has driven significant advancements in the field of molecular pathology research.
Invasive Lobular Carcinoma (ILC)
are a common special subtype of breast cancer comprising up to 15% of all cases. They exhibit a very characteristic set of clinical, pathological and biological properties, including a progressive decline in survival, an infiltrative pattern of growth and down regulation of cell adhesion molecule, E-cadherin. Morphological variants exist that are associated with a worse outcome compared to the classic type. A large component of Peter's research focuses on aspects of this specific disease subtype, including understanding molecular determinants that predict tumour behaviour, and mechanisms of invasion and metastasis.
The National Health and Medical Research Council (NHMRC)
The National Breast Cancer Foundation (NBCF)
The University of Queensland